TCS 359
TCS 359
CAS: 301305-73-7
Molecular Formula: C18H20N2O4S
TCS 359 - Names and Identifiers
TCS 359 - Physico-chemical Properties
| Molecular Formula | C18H20N2O4S |
| Molar Mass | 360.43 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Boling Point | 454.4±45.0 °C(Predicted) |
| Solubility | H2O: <2mg/mL |
| Appearance | White solid |
| Color | white to off-white |
| pKa | 12.43±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Sensitive | Light Sensitive |
| MDL | MFCD00617269 |
| Use | 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide |
| In vitro study | TCS 359 is a potent inhibitor of FLT3 with an IC50 of 42 nM. TCS 359 inhibited cell proliferation by MV4-11 with an IC50 of 340 nM. Among a group of kinases, TCS 359 acts with high selectivity on FLT3. |
TCS 359 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
TCS 359 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.774 ml | 13.872 ml | 27.745 ml |
| 5 mM | 0.555 ml | 2.774 ml | 5.549 ml |
| 10 mM | 0.277 ml | 1.387 ml | 2.774 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.555 ml |
Last Update：2024-01-02 23:10:35
TCS 359 - Reference Information
| biological activity | TCS 359 is an effective FLT3 inhibitor with IC50 of 42 nM. |
| in vitro study | TCS 359 is an effective inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibited the proliferation of MV4-11 cells with IC50 of 340 nM. In a group of kinases, TCS 359 act on FLT3 with high selectivity. |
| feature | TCS 359 is valid and selective. |
| target | IC50: 42 nM (FLT3) |
Last Update：2024-04-09 20:52:54
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View History
TCS 359
CLOXATHIEPIN
Ethane, nitro-, ion(1-), lithium (9CI)
ALMITRINE BISMESYLATE
(1R,2S,5S)-3-(((9H-芴-9-基)甲氧基)羰基)-6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-羧酸
1-(3-氨基苯并呋喃-2-基)乙酮
2,2',4,4',5-PENTABROMODIPHENYL ETHER
(1S,2S)-1,2-双(4-甲氧基苯基)乙二胺
Pyrocatechuic acid
Piperacillin methyl ester impurity
CLOXATHIEPIN
Ethane, nitro-, ion(1-), lithium (9CI)
ALMITRINE BISMESYLATE
(1R,2S,5S)-3-(((9H-芴-9-基)甲氧基)羰基)-6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-羧酸
1-(3-氨基苯并呋喃-2-基)乙酮
2,2',4,4',5-PENTABROMODIPHENYL ETHER
(1S,2S)-1,2-双(4-甲氧基苯基)乙二胺
Pyrocatechuic acid
Piperacillin methyl ester impurity